Special Issue on Recent Advances in Immunohistochemical Markers Used for Targeted and Immunotherapy

Submission Deadline: Apr. 10, 2020

Please click the link to know more about Manuscript Preparation: http://www.crjournal.org/submission

This special issue currently is open for paper submission and guest editor application.

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Special Issue Flyer (PDF)
  • Lead Guest Editor
    • Marwa Shakweer
      Department of Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
  • Guest Editor
    Guest Editors play a significant role in a special issue. They maintain the quality of published research and enhance the special issue’s impact. If you would like to be a Guest Editor or recommend a colleague as a Guest Editor of this special issue, please Click here to complete the Guest Editor application.
    • Lobna Shash
      Department of patholgogy,Faculty of Medicine Ain Shams University, Cairo, Egypt
    • Ghada Refaat
      Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    • Riham Abu Zeid
      Department of pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    • Malames Faisal
      Obstetrics and gynecology department, Faculty of medicine, Ain Shams University, Cairo, Egypt
    • Faten Ghazal
      Department of pathology, Faculty of Medicine, Ain shams university, Cairo, Egypt
    • Maha Behairy
      Nephrology department, faculty of medicine, Ain Shams University, Cairo, Egypt
    • Nevila Heta
      Biochemical Laboratory QSUT, Tirane, Albania
  • Introduction

    In the last few decades treatment of cancer based on targeted and immunotherapy has been a point of great concern especially in researches and clinical trials to minimize side effects arising from chemotherapy. Targeted therapy works by targeting the cancer’s specific genes, proteins, or the tissue environment that contributes to cancer growth and survival. Moreover, it was found that targeted therapy should be tailored for each patient according to genetic basis being an integral core for precision medicine.
    The decision of targeted therapy is based on either immunohistochemistry and or genetic analysis. An example of the well known applied targeted therapy include, the use of BRAF inhibitors in melanoma, Her2 blockers in breast carcinoma, cases of lung cancer with ALK and ROS gene mutations.
    As for cancer stem cells, it was hypothesized that their targeting could eradicate the whole cancer. CSC surface markers provide molecular targeted therapies for various cancers, using therapeutic antibodies specific for the CSC surface markers.
    Researches are now held to explore possible stem cell markers with clinical trials on the effect of their targeting.
    Treatment by immunotherapy has been approved by FDA for small cells lung cancer, malignant melanoma, bladder cancer, and still researches are ongoing to detect its efficacy in other malignancies.
    Immunohistochemistry is considered a simple affordable method which is used for prediction of efficacy of targeted and immunotherapy in certain malignancies.
    The aim of this special issue is to include researches concerned with recent advances in the role of immunohistochemistry for targeted or immunotherapy in various tumors and whether it has prognostic value.

    Aims and Scope:

    1. targeted therapy
    2. immunotherapy
    3. stem cell markers
    4. immunohistochemistry
    5. prognostic markers
    6. biomarkers

  • Guidelines for Submission

    Manuscripts can be submitted until the expiry of the deadline. Submissions must be previously unpublished and may not be under consideration elsewhere.

    Papers should be formatted according to the guidelines for authors (see: http://www.crjournal.org/submission). By submitting your manuscripts to the special issue, you are acknowledging that you accept the rules established for publication of manuscripts, including agreement to pay the Article Processing Charges for the manuscripts. Manuscripts should be submitted electronically through the online manuscript submission system at http://www.sciencepublishinggroup.com/login. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal and will be listed together on the special issue website.

  • Published Papers

    The special issue currently is open for paper submission. Potential authors are humbly requested to submit an electronic copy of their complete manuscript by clicking here.